An investigation of 125I seed permanent implantation for recurrent carcinoma in the head and neck after surgery and external beam radiotherapy
Background: A preliminary assessment was conducted of the feasibility, efficacy, and morbidity of 125I seed implantation for recurrent head and neck carcinoma after surgery and external beam radiotherapy.Methods: Nineteen patients with recurrent head and neck carcinomas underwent 125I seed implantation under ultrasound or computed tomography guidance.The actuarial D90 of 125I seed implantation ranged from 90 to 160 Gy (median, 131 Gy).The follow-up period ranged from 3 to 44 months (median, 11 months).Results: The median local control was 24 months (95% confidence interval, 10.2 to 37.8).The one-year, two-year and three-year local controls were 73.3%, 27.5% and 27.5%, respectively, whereas the one-year, two-year and threeyear survival rates were 53.0%, 18.2% and 18.2%, respectively, and the median survival was 13 months (95%confidence interval, 6.6 to 19.4).A total of 26.3% of patients (5/19) died of local recurrence and 21.1% of patients (4/19) died of metastases.One suffered from a grade 1 skin reaction.Conclusions: 125I seed implantation is feasible and safe as a salvage treatment for patients with recurrent head and neck cancers.The high local control results and low morbidity merits further investigation.
125I seed Head and neck carcinoma Surgery External beam radiotherapy
Lihong Zhu Yuliang Jiang Junjie Wang Weiqiang Ran Huishu Yuan Chen Liu Ang Qu Ruijie Yang
Department of Radiation Oncology, Peking University 3rd Hospital, No.49 Huayuan North road, Haidian district, Beijing 100191, People”s Republic of China
国内会议
北京大学医学部近距离放疗研究中心成立大会暨北京大学第三届国际放射肿瘤学术论坛
北京
英文
2-8
2013-05-24（万方平台首次上网日期，不代表论文的发表时间）