Preliminary results of 125I interstitial brachytherapy for locally recurrent parotid gland cancer in previously irradiated patients
Background.The purpose of this study was to analyze the treatment of recurrent parotid gland cancers with radioactive iodine (125I)seed implantation.Methods.Fifteen patients with recurrent previously irradiated parotid gland cancers were treated with postoperative 125I seed implantation between April 2004 and June 2009.Local control, survival rates, and side effects were retrospectively reviewed.Results.The 3-year and 5-year local control rates were 67% and 53.6%,and the overall survival rates were 76.2% and 66.7% respectivety.Four patients with House-Brackman (H-B) grade N cancer recovered to grade Ⅱ during follow-up.Four patients (26.7%) developed grade Ⅳ skin ulceration.Two patients (13.3%) developed moderate fibrosis of the subcutaneous tissues, and 2 patients (13.3%) had hearing loss for 1year after brachytherapy,Conclusion.This study showed excellent local control and a good survival rate in patients who received 125I brachytherapy.These findings should be interpreted cautiously due to the small number of patients and the relatively short follow-up.(C) 2012 Wiley Periodicats, Inc.Head Neck 34:1445-1449, 2012.
parotid gland cancer 125I seed interstitial brachytherapy recurrent radiation
Lei Zheng Jianguo Zhang Jie Zhang Tieli Song Mingwei Huang Guangyan Yu
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, People”s Republic of China
国内会议
北京大学医学部近距离放疗研究中心成立大会暨北京大学第三届国际放射肿瘤学术论坛
北京
英文
25-29
2013-05-24（万方平台首次上网日期，不代表论文的发表时间）