c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation
Hormone-refractory prostate cancer shows substantial resistance to most conventional therapies includ ing radiotherapy, constitutes a key impediment to curing patients with the disease, c-Met overexpression plays a key role in prostate cancer tumorigenesis and disease progression.Here, we demonstrate that c-Met inhibition by SU11274 could significantly suppress cell survival and proliferation as well as enhance the radiosensitivity of DU145 cells.The underlying mechanisms of the effects of SU11274 on DU145 cells may include the inhibition of c-Met signaling, depolarization of the mitochondrial mem brane potential, impairment of DNA repair function, abrogation of cell cycle arrest, and enhancement of cell death.Our study is the first to show the effectiveness of combining c-Met inhibition with ionizing radiation to cure horrnone-refractory prostate cancer.
c-Met inhibitor Prostate cancer cells Radiosensitivity
Hongliang Yu Xiaoying Li Shaoqian Sun Xianshu Gao Demin Zhou
Department of Radiation Oncology, Peking University First Hospital.Peking University, Beijing,China Stare Key Laboratory of Natural and Biomimetic Drugs, school of Pharmaceutical Sciences, Peking Univ
国内会议
北京大学医学部近距离放疗研究中心成立大会暨北京大学第三届国际放射肿瘤学术论坛
北京
英文
127-132
2013-05-24（万方平台首次上网日期，不代表论文的发表时间）