Genetic Variants In BMP8B Gene Are Associated With Growth Traits in Chinese Native Cattle
As a signaling molecule, bone morphogenetic protein 8B (BMP8B) plays an essential role in bone metabolism and is able to regulate thermogenesis and energy balance, which suggests that BMP8B gene may be a new candidate for growth traits.Here, to characterize the effects of BMP8B gene on growth traits, we first used Chinese indigenous cattle breed, Qinchuan cattle (n =396), to detect single nucleotide polymorphisms (SNPs).Five novel SNPs of BMP8B gene (g.-242C>T, g.2164C>T, g.2639T>C, g.2900C>G and g.10817C>T) were identified by DNA pool sequencing and forced PCR-RFLP.And then we associated the five SNPs with four growth traits (body weight, body length, heart girth, and hucklebone width).Results from association analysis showed that the SNP 1, 2, and 3 affected growth trait(s) markedly (P < 0.05).Further, 6 combined haplotypes were constructed to guarantee the reliability of analysis results.There were also significant differences in body length, heart girth and body weight between the 6 combined haplotypes (P < 0.05), but not in hucklebone width (P > 0.05).Collectively, our results suggest a modulatory role of BMP8B gene in cattle growth and development, and 3 SNPs could be used as molecular markers in early marker assisted selection (MAS) in beef cattle breeding program.
BMP8B gene Qinchuan cattle combined haplotype growth traits
Xiukai Cao Hong Chen
College of Animal Science and Technology, Northwest A&F University, Yangling, China, 712100 College of Animal Science and Technology, Northwest A&F University, Yangling, China, 712100;National
国内会议
第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
陕西杨凌
英文
74-81
2013-10-22（万方平台首次上网日期，不代表论文的发表时间）