Analysis Of Genetic Variations and Haplotypes with in MEF2C Gene Reveals Significant Effect of Growth Traits in Cattle
The myocyte enhancer factor 2C (MEF2C) is atranscription factor that play a pivotal role in the muscle development.In this study, we aimed to detect variations of the MEF2C gene in 575 individuals representing two Chinese cattle breeds by sequencing pooled DNA samples (Pool-Seq) and forced polymerase chain reaction-restriction fragment length polymorphism (Forced PCR-RFLP) methods, and to analyze their effects on growth traits.A total of four novel SNPs were identified and they were all located non-coding region.We also investigated haplotype frequencies and linkage disequilibrium coefficients for four SNPs in all study populations.There were seven haplotypes inferred and the linkage disequilibrium was assessed in the two cattle breeds.The association analysis indicated that the C allele of SNP 1 locus and the combined genotype H1H6 (or H3H5) (TC-CT-GG-AA) showed a significant effect on growth traits such as body height (BH), height at hip cross (HHC) and rump length (RL) in Qinchuan cattle (P<0.05).These data reveal that variations and haplotypes within the MEF2C gene are associated with growth traits, and may be considered as molecular markers for economic traits in beef cattle breeding program.
Association Cattle Growth traits Variations Haplotypes
ZhaoYang Zhan YongZhen Huang XianYong Lan Hong Chen
College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, P.R.China, 712100
国内会议
第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
陕西杨凌
英文
177-180
2013-10-22（万方平台首次上网日期，不代表论文的发表时间）