Snps of Bovine HGF Gene and Their Association With Growth Traits in Nanyang Cattle
Hepatocyte growth factor (HGF) is one of the multifunctional cell factors that regulates cellular proliferation, motility and morphngenesis in mammalians.And its medical research has deep significance.In this paper, polymorphisms of HGF gene were investigated in 1433 health and irrelated Chinese cattle by PCR-RFLP and DNA sequencing approach.Ten novel Single Nucleotide Polymorphisms (SNPs) were identified, which included one missense mutation, g.72801G>A in the coding region, and the others in the intron.Association analysis between four of them, g.288T>C, g.72801G>A, g.77172G>T, and g.77408T>G, and growth traits in Nanyang, were performed.The results indicated that SNPs within bovine HGF gene were significantly associated with growth traits.Phylogenetic analysis showed that the genetic background of Caoyuan Red cattle was different from the others in the tested breeds.The findings will provide a background for application of hnvine HGF gene in the selection program in Chinese cattle.
Chinese cattle Growth traits HGF gene SNPs
HanFang Cai XianYong Lan AiMin Li Yang Zhou JiaJie Sun Chuzhao Lei ChunLei Zhang Hong Chen
College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agricultur Institute of Cellular and Molecular Biology, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, Peo
国内会议
第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
陕西杨凌
英文
195-203
2013-10-22（万方平台首次上网日期，不代表论文的发表时间）