IL-17 Promotes Type 1 T Cell Response Through Modulating Dendritic Cell Function in Acute Allograft Rejection
IL-17 is a cytokine produced by various type cells.Previous studies have shown that IL-17 plays a critical role in the pathogenesis of diseases.However,less study has addressed the source of IL-17 and its mechanism in the development of allograft rejection response.Here we found that IL-17 expression was obviously up-regulated at the early stage of cardiac allograft rejection.These IL-17 are predominantly produced by CD3+ T cells,whereas IL-17 is rarely expressed by CD11c,CD11b,and NK1.1 positive cells.Interestingly,CD3 positive γδT cells also contributed to IL-17 production,and DC maturation was following the early elevated IL-17 expression during the alloimmune response,and it was worth noting that blockage of endogenous IL-17 activity suppressed DC maturation and decreased inflammatory cytokines during acute allograft rejection.Furthermore,as expected,we found that recombinant IL-17 significantly up-regulated costimulatory molecules of bone marrow derived dendritic cells (BMDCs) in vitro,and IL-17-treated BMDCs showed an increased capacity to enhance T cell function.In conclusion,our data provide clear evidence that early elevated IL-17 contributes to allograft rejection through modulating DC function.
IL-17 allograft rejection DC
Lihua DUAN Jie CHEN Quansong XIA Min FANG Fang ZHENG Guixiu SHI Feili GONG
Department of Rheumatology and Clinical Immunology,The First Hospital of Xiamen University,Xiamen,36 Basic Medical Department of Medical College,Xiamen University,Xiamen,361005,China Department of Immunology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,
国内会议
昆明
英文
1-10
2014-05-24（万方平台首次上网日期，不代表论文的发表时间）