Sublytic C5b-9 Induces IL-6 and TGF-β1 Production by Glomerular Mesangial Cells Through p300-Mediated C/EBPβ Acetylation
The increased production of IL-6 and TGF-β1 by glomerular mesangial cells (GMC) in rat Thy-1 nephritis (Thy-1N),a model of human mesangioproliferative glomerulonephritis (MsPGN),is accompanied by sublytic C5b-9 deposition,but the mechanism of IL-6 and TGF-β1 up-regulation in rat GMC triggered by sublytic C5b-9 in this model has not been elucidated.We found that sublytic C5b-9 could induce the production of IL-6 and TGF-β1 through up-regulation of p300 and C/EBPβ expression in GMC.Besides,C/EBPβ-enhanced IL-6 and TGF-β1 gene activation and p300-mediated C/EBPβ acetylation were involved in the up-regulation of IL-6 and TGF-β1 in GMC attacked by sublytic C5b-9.Together,these data implicate that mechanism of IL-6 and TGF-β1 production in GMC is associated with sublytic C5b-9-upregulated p300 and p300-mediated C/EBPβ acetylation as well as C/EBPβ-activated IL-6 and TGF-β1 genes.
transcription factor post-translational modification renal inflammation renal pathology
Jing ZHANG Yingwei WANG Yan LI Kai SHAN Lulu WANG Wen QIU Yanlai LU Dan ZHAO Gangqian ZHU Fengxia HE
Department of Microbiology and Immunology,Nanjing Medical University,Nanjing,210029,China
国内会议
昆明
英文
1-6
2014-05-24（万方平台首次上网日期，不代表论文的发表时间）