会议专题

Tumor-Infiltrating Immune Cells:Triggers for Tumor Capsule Disruption and Tumor Progression?

  Background: Our previous studies of human breast and prostate cancer have shown that aberrant immune cell infiltration is associated with focal tumor capsule disruption and tumor cell budding that facilitate invasion and metastasis.Our current study attempted to determine whether aberrant immune cell infiltration would have similar impact on colorectal cancer (CRC).Materials and Methods: Tissue sections from 100 patients with primary CRC were assessed for the frequencies of focal basement membrane (BM) disruption, muscularis mucosa (MM) frag-mentation, and tumor cell dissemination in epithelial structures adjacent and distal to infiltrating lymphoid aggregates using a panel of biomarkers and quantitative digital imaging.Results: Our study revealed: (1) epithelial structures adjacent to lymphoid follicles or aggregates had a significantly higher (P<0.001) frequency of focally disrupted BM, dissociated epithelial cells in the stroma, disseminated epithelial cells within lymphatic ducts or blood vessels, and fragmented MM than their distal counterparts, (2) a majority of dissociated epithelial cells within the stroma or vascular structures were immediately subjacent to or physically associated with infiltrating immune cells, (3) the junctions of pre invasive and invasive lesions were almost exclusively located at sites adjacent to lymphoid follicles or aggregates, (4) infiltrating immune cells were preferentially associated with epithelial capsules that show distinct degenerative alterations, and (5) infiltrating immune cells appeared to facilitate tumor stem cell proliferation, budding, and dissemination.Conclusions: Aberrant immune cell infiltration may have the same destructive impact on the capsule of all epithelium-derived tumors.This, in turn, may selectively favor the proliferation of tumor stem or progenitor cells overlying these focal disruptions.These proliferating epithelial tumor cells subsequently disseminate from the focal disruption leading to tumor invasion and metastasis.

Bin Jiang Xichen Zhang Yan-gao Man Jeffrey Mason Anahid Jewett Min-ling Liu Wen Chen Jun Qian Yijiang Ding Shuqing Ding Min Ni

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital, Nanjing University of College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China;Diagnos Laboratory of Proteomics and Protein Science, Veterans Affairs Medical Center, Washington, DC, USA Tumor Immunology Laboratory, Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Cen Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, USA

国内会议

第十六届中国中西医结合学会大肠肛门病专业委员会学术会议

广州

英文

300-315

2013-08-01(万方平台首次上网日期,不代表论文的发表时间)