Lipid matrix particles as oral drug delivery vehicles
Lipid matrix particles may have great potentials in oral drug delivery,especially for biopharmaceuticals by protecting them from enzymatic degradations in the gastrointestinal tract and thereby enhancing drug absorption and bioavailability.Lipids vary in their physiochemical properties as well as their digestibility and absorption pathways,therefore selection of lipid excipients has pronounced effects on drug absorption.A better understanding on the mechanisms of drug release from lipid particles is also essential for designing functional drug carriers.The drug release mechanism from lipid matrix particles was studied using an in vitro lipolysis model,desmopressin and lysozyme were used as model peptide/protein drugs.The results showed that the chain-length of fatty acyl groups of lipid excipients affected the rate of drug release,which decreased with the increase of chain-length of fatty acyl groups of triglycerides.The release of peptide/protein drugs from triglyceride particles was governed by lipase and lipid degradation,whereas the release of drugs from monoglyceride particles was independent on the presence of the lipase.The understanding on drug release mechanisms provides the possibility for designing of lipid carriers with desired drug release profiles.
biopharmaceuticals in vitro lipolysis lipid matrix particles lymphatic transport poorly water-soluble drugs
Huiling Mu
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
国内会议
乌鲁木齐
英文
30-34
2013-09-21（万方平台首次上网日期，不代表论文的发表时间）