Multifunctional Graphene Oxide as drug delivery carriers for cancer targeted chemo-photothermal therapy
The covalent functionalization of graphene oxide (GO) with hyaluronic acid (HA) was successfully accomplished by a facile amidation process.The HA-GO nanosheets with a good aqueous solubility and biocompatibility were characterized FT-IR and UV/Vis spectroscopy.Furthermore,controlled loading of mitoxantrone (MIT) onto the HA-GO via π-π stacking interaction was investigated.The results revealed that drug-loaded nanosheets with high loading efficiency of 50 wt%,exhibited pH-sensitive responses to tumor pH.In order to investigate the dynamic behaviors and targeting ability of HA-GO nanosheets on tumor-bearing mice,near-infrared fluorescent (NIFR) dye Cyanine 7 (Cy7) was encapsulated into the nanosheets for in vivo optical imaging.It demonstrated that HA-GO nanosheets could enhance the targeting and residence time in tumor site.Therefore,the MIT/HA-GO nanosheets may potentially be useful to be further development of synergistic cancer therapy.
Graphene oxide Drug delivery carrier Photothermal therapy Chemotherapy Cancer
Lin Hou Qianhua Feng Yating Wang Zhenzhong Zhang
School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue,Zhengzhou 450001, Henan, P.R. China
国内会议
乌鲁木齐
英文
132-135
2013-09-21（万方平台首次上网日期，不代表论文的发表时间）