Preparation and properties of traditional chinese medicine Drynariae Rhizoma-Porcine Bone Hydroxyapatite- Chitosan porous biomaterials
The respective advantages of porcine bone hydroxyapatite (PBHA) and chitosan (CS) were combinated together,Chinese medicine Drynariae Rhizoma (DR) was introduced into bone repair materials for the purpose of good osteoindaction,DR-PBHA-CS porous composite biomaterials was fabricated by the Vacuum freeze drying method.The compressive strength of the porous biomaterials and the porosity was tested.The microscopic morphology and components of the biomaterials were analyzed by SEM,XRD and IR,Respectively biological activity of the porous biomaterials were studied by Simulated Body Fluid (SBF) and rabbit in vivo implantation.Results show that: The pore structure of the porous biomaterials is cellar-shaped,PBHA distributed homogeneously in the pore walls.With an increasing content of CS,the porosity of the porous biomaterials gradually increase and the compressive strength gradually decrease.Bone-like apatite form on the surface of the materials after immersion in SBF.The introduction of the DR speeds up the formation and maturity of new bone by histological observation,with bone density of bone defect region increases gradually,which shortens the osteogenesis period.
Drynariae Rhizoma Chitosan Porcine bone hydroxyapatite Vacuum freeze drying Tissue engineering scaffold
WANG Jingyan LI Muqin LIU Zheng WEI Jingbao
Provincial Key Laboratory of Biomaterials,Jiamusi University,Jiamusi,154007,China
国内会议
北京
英文
121-127
2013-09-10（万方平台首次上网日期，不代表论文的发表时间）