Dual effects of molybdenum on mouse oocyte quality and ovarian oxidative stress
In order to investigate the effects of molybdenum (Mo) on the ovarian functions, a sub-acute toxicity test was performed in this study.The ICR strain of adult female mice was exposed to Mo by free access to the distilled water containing the Mo at 5, 10, 20 and 40 mg/L for 14 days.Compared to control, the M Ⅱ oocyte morphology, ovary index, ovulation were improved by Mo at 5 mg/L, but were negatively affected by Mo at 40 mg/L.Abnormal mitochondria morphologies were observed in ovarian cells at ≥ 20 mg/L groups.All these alterations were accompanied with the changes in SOD, GPx and MDA levels in ovaries.In conclusion, Mo affects the oocyte quality possiblythrough regulating the ovarian oxidative stress in a dose-dependent manner.Especially, the Mo improves ovarian functions at a suitable concentration, which might be a novel drug candidate for the treatment of female infertility.
Molybdenum Oxidative stress Ovary Oocyte Granulosa cells Mouse
Xiao-Li Chen Qiao Qi Zhi-Jie Liu Feng-Jun Liu Yu-Ling Zhang Zi-Qiang Zhang Run-Zhe Shu Xue-li Yu Xiao-Wei Zhai Li-Jun Jin Xue-Gang Ma
College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,P College of Veterinary Medicine,Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Devel Monash Immunology and Stem Cell Laboratories,Monash University,Clayton 3800,Australia
国内会议
郑州
英文
6-10
2013-11-24（万方平台首次上网日期，不代表论文的发表时间）