Antiproliferative Activity of Ethanolic Extract from Dryopteris Fragrans (L.) Schott on PC-3M Cells

摘要：

　　Recently, the mortality rates of prostate cancer in Asian countries are rising steadily.Dryopteris fragrans (L.) schott has been safely used for years as a folk remedy in No,heast China (Chinese name: Xiang-Lin-Mao-Jue).In this study, antiproliferative activity of ethanolic extract from D.fragrans was investi gated for the first time.Through the results of MTT test, clone formation assay and morphological observa tion, a short-term or long-term growth inhibition was significantly increased in a time-and dose-dependent manner with cell shrinkage and cytoplasm vacuolization.Further cell cycle distribution analysis indicated that the antiproliferative activity of ethanolic extract from D.fragrans was related to inhibition of G1 to S phase and G2phase transition during mitosis on human prostate cancer PC-3M cells.

关键词： Dryopteris fragrans (L.) Schott ethanolic extract antiproliferative activity PC-3M cells

作者: Dandan ZHAO Wenrui LI Weimin ZENG Yue LI Xiaoguang YU Yanlong ZHANG

作者单位: Province Key Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin, C Province Key Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin, C Province Key Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin, C Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Harbin Medical U

会议类型: 国内会议

会议名称: 中华民族医药资源保护与开发应用高峰论坛

会议地点: 重庆

会议语种:英文

页码: 340-342

在线出版日期: 2011-12-14（万方平台首次上网日期，不代表论文的发表时间）