细胞周期与基因组不稳定性

摘要：

Chromosomal instability is a major characteristic of human cancer.The abnormality can result from defects in cell cycle regulation, including the spindle assembly checkpoint, which is a surveillance mechanism for accurate chromosome segregation through restraint of the activity of the anaphase-promoting complex/cyclosome (APC/C).DNA damageinduced by radiation challenges thegenetic integrity of cells, and DNAresponse (DDR) activates checkpoint pathways to trigger cell cycle arrest and allow the time for DNA repair beforeundertaking important events such as replication or mitosis.

关键词： 细胞周期 基因组 不稳定性

作者: 张学敏

会议类型: 国内会议

会议名称: 第11届全国脂质与脂蛋白学术会议

会议地点: 太原

会议语种:中文

页码: 3-3

在线出版日期: 2012-09-21（万方平台首次上网日期，不代表论文的发表时间）