A novel basic fibroblast growth factor delivery system fabricated with heparin-incorporated fibrin-fibronectin matrices for repairing rat sciatic nerve disruptions
Autologous nerve gratis are widely used in bridging critical gaps of peripheral nerves,but they remain associated with high morbidity of the donor site and lack of full recovery.As an alternative,we have focused on chitosan nerve conduits filled with a heparin-incorporated fibrin-fibronectin matrix serving as delivery systems for basic fibroblast growth factor (bFGF).The artificial nerve conduits were used for repairing sciatic nerve defects of 10 mm in adult rats.Three months post-operation,the conduction velocity recovery index (CVRI) and the muscle restoration rate (MRR) in animals of the experimental group were 32 ± 4.1 and 77.4 ± 7.9%,respectively,which were significantly higher than those of the PBS control group (17.8 ± 1.9 and 66.7 ± 6.5%),and similar to those of the autograft group (38.4 ± 3.9 and 81.3 ± 7.8%).These results were also consistent with the densities of regenerated axons in the three groups,which were demonstrated by histomorphological analysis.
Basic fibroblast growth factor Chitosan Fibrin Fibronectin Heparin Peripheral nerve regeneration
韩宏彦 敖强 陈国强 王世杰 左焕琮
Institute of Neurological Disorders, Yuquan Hospital, Tsinghua University, Beijing 100049, China
国内会议
北京医学会神经外科学分会暨北京医师协会神经外科专业专家委员会2010年北京神经外科年会
北京
英文
213-219
2011-01-07（万方平台首次上网日期，不代表论文的发表时间）