Ertapenem versus ceftriaxone based therapy for the treatment of complicated infections:meta-analysis of randomized controlled trials:ertapenem for the treatment of complicated infections:a meta-analysis
Background: The aim of this study is to compare the efficacy and safety of ertapenem with ceftriaxone based therapy,which has been demonstrated to be highly effective for the complicated infections.Methods: We searched PubMed,EMBASE,and the Cochrane Library for published randomized controlled trials that compared the efficacy and safety of ertapenem with ceftriaxone based therapy for the treatment of complicated infections including CAP,cUTIs,and cIAIs.Meta-analysis was performed by RevMan 5.0.Result: 8 RCTs,involving 2883 patients,were included in our meta-analysis.Ertapenem was associated similar clinical treatment success with ceftriaxone based therapy for complicated infections (1326 patients,FEM,OR: 1.13,95CI%:0.75-1.71).There was no difference between the compared treatment groups regarding microbiological success.And no difference was found regarding the incidence of clinical and laboratory drug-related adverse events between ertapenem and ceftriaxone groups.As to local tolerability,overall,there was no difference between the compared groups,however,in the subgroup analysis,local reaction was significantly less in ertapenem subgroup than ceftriaxone plus ceftriaxone subgroup.Conclusion: This meta-analysis provides evidence that ertapenem can be used as effectively and safely as ceftriaxone,for the treatment of complicated infections.It is an appealing option for the treatment of these complicated infections.
ertapenem ceftriaxone complicated infections meta-analysis
Nan Bai Chunguang Sun Rui Wang Wang Jin Yun Cai Beibei Liang Lei Zhang Youning Liu
Medicine Clinical Research center,Chinese PLA General Hospital,28 Fuxing Road,Beijing,PR China Department of Respiratory Diseases,Chinese PLA General Hospital,28 Fuxing Road,Beijing,PR China
国内会议
南宁
英文
1-34
2013-11-01（万方平台首次上网日期，不代表论文的发表时间）