Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction:Role of TGF-β1-TAK1

摘要：

　　Inhibition of Rho-kinase displays vasodilation property although its effect on cardiac remodeling in heart against pressure overload and ischemia has not been fully elucidated.The present study was designed to examine the effect of fasudil,a Rho-kinase (ROCK) inhibitor,on myocardial remodeling and underlying mechanisms in pressure overload and myocardial infarction (MI) mice.Pressure overload was produced by constriction of the transverse aorta (TAC) for 3 weeks.

关键词： Rho-kinase TAC MI myocardial fibrosis TGF-β1-TAK1

作者: Qin Li Yuan Xu Xiaoyu Li Yankun Guo Gaolin Liu

作者单位: Department of Pharmacology,Shanghai First People”s Hospital,School of medicine,Shanghai Jiao Tong University,Shanghai,China

会议类型: 国内会议

会议名称: 2013中国药学大会暨第十三届中国药师周

会议地点: 南宁

会议语种:英文

页码: 1-16

在线出版日期: 2013-11-01（万方平台首次上网日期，不代表论文的发表时间）