A three-year survey of the antimicrobial resistance of microorganisms from a Chinese teaching hospital
Objective: To survey the bacterial resistance of antibiotics in a teaching hospital.Methods: A retrospective study was carried out for antibiotic susceptibility of bacteria in a university hospital from 2009 to 2011.Antimicrobial susceptibility was performed by standard Kirby-Bauer disk diffusion.Data were analyzed using WHONET 5.5 software.Results: Escherichia coli was the most prevalent bacterium in the survey at 16.2,20.0,and 19.6% of cases and followed by Acinetobacter baumannii at 12.0,12.5 and 16.9% for 2009,2010,and 2011,respectively.Staphylococcus aureus was a distant third with an increasing trend.E.coli had resistance rates up to 70% or more for penicillins (ampicillin,piperacillin,ampicillin/sulbactam),some cephalosporins (e.g.cefuroxime,cefotaxime,cefaclor) and other antibiotics (such as ciprofloxacin,trimethoprim and sulphamethoxazole,gentamicin).It was sensitive to imipenem and meropenem,although resistance to meropenem went up by 0.2% in 2011.For S.aureus,the resistance rate for common antibiotics was over 70% but no resistance to linezolid,vancomycin,and teicoplanin.A.baumannii had a resistance rate over 60% to almost all antibiotics,but less to cefoperazone/sulbactam,44.6% and 26.1% for 2009 and 2011,respectively.For Pseudomonas aeruginosa,the resistance rate against the majority of antibiotics was around 20%,and 10% against cefoperazone/sulbactam,piperacillin,and amikacin.In 2011,Enterococcus faecalis had a resistance rate of 55.6% against levofloxacin and E.faecium,53.2%.However,both were susceptible to linezolid,vancomycin,and teicoplanin.Resistance rates for methicillin-resistant Staphylococcus aureus were 63.2,65.8,and 60.1%,and methicillin-resistant coagulase-negative staphylococci,68.0,71.6,and 68.5%,for the years 2009,2010,and 2011,respectively.Conclusion: This survey showed an increasing trend in the resistance to antibiotics in recent years.While there is a need for the discovery of more effective antibiotics,more stringent adherence to guidelines on the use of antibiotics is advocated.
Bacterial infection antimicrobial resistance Escherichia coli Acinetobacter Staphylococcus aureus
TANG Jing LIU Gaolin
Department of Pharmacy,Shanghai First People”s Hospital,School of Medicine,Shanghai Jiaotong University,100 Haining Road,Shanghai,200080 China
国内会议
南宁
英文
1-23
2013-11-01（万方平台首次上网日期，不代表论文的发表时间）