The characteristic of 76 HIV/AIDS patients with the onset of pulmonary infection
Objectives: In order to find the risk factor of CAP and progressing to severe pneumonia or respiratory failure in AIDS patients,the clinical data of patients with newly diagnosed AIDS was summarized.Methods: 79 patients who were newly diagnosed with HIV/AIDS in Ruijin Hospital between January 1998 and August 2011 were enrolled.The patients were divided into CAP group (Group A) and non-CAP group (Group B) according to whether complicating with CAP.The general condition and laboratory result in the two groups were compared.Logistic regression was used to analysis the relationship between the various kinds of clinical features and CAP.Furthermore,the Group A was divided into severe pneumonia group (Group A1) and non-severe pneumonia group (Group A2).The general condition and laboratory result in the two groups were compared,too.The multiple stepwise regression was used to study the relationship between the clinical characteristics of group A and hypoxemia.Results: Group A(n=39) was significantly older than group B(43.00±17.00 vs 37.00±13.00 P<0.05).The serum albumin (25.60 ± 5.31 vs 34.00 ± 6.90 P <0.05) and CD4 cell count (23.65 ± 31.15 vs 229.50 ± 229.45 P <0.05) of group A were much lower than those of group B.The level of serum albumin (RR = 0.6 P <0.01 95% CI: 0.38 ~ 0.93) and CD4 cell count (RR = 0.97 P < 0.05 95% CI: 0.94-1.00) negatively correlated with the incidence of CAP.The majority of chest images showed exudative changes (35.8%) and interstitial lesions (30.7%).Meanwhile,the CD4 cell count (27.65 ± 13.30 vs 71.50 ± 80.45 P <0.05) and partial pressure of oxygen (7.86 ± 1.43 vs 9.41 ± 2.15 P <0.05) of group A1 were significantly lower than those of group A2.Low serum albumin (β = 0.39 P <0.01 95% CI:0.19-0.59) and high blood urea nitrogen (β =- 0.40 P <0.05 95% CI: -0.74 ~ -0.05) is the risk factor of hypoxemia in group A.Conclusion: Early screening and diagnosis of AIDS,nutritional support,anti-viral treatment will prevent AIDS patients to develop CAP or progress to severe pneumonia,respiratory failure.
AIDS CAP severe pneumonia respiratory failure risk factors
Bao ZY Rong XJ Gong QM Shi GC Wan HY
Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, C Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025,
国内会议
第五届国际艾滋病临床影像学术会议暨第三届全国感染及传染病影像学最新进展学术会议
北京
英文
1-19
2012-11-09（万方平台首次上网日期，不代表论文的发表时间）