Characterization of the Candida parapsilosis complex in East China:species distribution differs among cities
Candida parapsilosis,which was previously considered to be a complex of three geneti-cally distinct groups,has emerged as a significant agent of nosocomial infections.Recently,this complex was separated into three species: C.parapsilosis sensu stricto,C.orthopsilosis and C.metapsilosis.In China,data pertaining to these fungi are lim-ited.In this study,we examined 57 isolates of members of the C.parapsilosis com-plex collected from four cities in East China,i.e.,Nanjing ( n=22),Nanchang (n=20),Shanghai (n=12) and Jinan (n=3).C.parapsilosis sensu stricto represented 71.9% of all isolates,while C.metapsilosis accounted for the remaining 28.1%.C.orthopsilosis could not be identifi ed.A significantly high prevalence of C.metapsilosis was observed in strains recovered from Nanchang,60% (12/20) of the isolates were C.metapsilosis.Sequence analysis of internal transcribed spacer region revealed two unevenly distrib-uted genotypes among the C.metapsilosis strains.A PCR-restriction fragment length polymorphism assay was described for rapid identification.The strains were susceptible to fluconazole,voriconazole,amphoterincin B and micafungin.Six (15%) isolates of C.parapsilosis sensu stricto and three (18.8%) of C.metapsilosis were found to be dose-dependent susceptible to itraconazole.C.parapsilosis sensu stricto strains were less susceptible to micafungin than C.metapsilosis.
Candida parapsilosis Candida metapsilosis identification distribution antifungal susceptibility
YI P. GE TEUN BOEKHOUT PING ZHAN. GUI X. LU YONG N.SHEN MIN LI HAI F. SHAO WEI D. LIU
Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Uni Centraalbureau voor Schimmelcultures Fungal Biodiversity Centre, Utrecht,The Netherlands Department of Mycology, Dermatology Hospital of Jiangxi Province, Nanchang,PR China Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Bas
国内会议
黄山
英文
78-90
2012-07-19（万方平台首次上网日期，不代表论文的发表时间）