Ability of TEP1 in intestinal flora to modulate natural resistance of Anopheles dirus
Malaria persists today as the most widespread and devastating protozoan disease of humans.Over 3 billion people live under the threat of malaria and it kills an estimated 655,000 individuals each year—mostly children under 5 years of age (WHO: World Malaria Report,2011,http://www.who.int/malaria/wodd_malaria_report_2011/en/).The causative agents of malaria are protozoan parasites of the genus Plasmodium,which are transmitted to an Anopheles mosquito vector when the female mosquito ingests an infected bloodmeal.Currently,the control of malaria has consisted of killing the mosquito vector,using physical barriers to limit vector—human contact,and treating infected individuals.Although in certain regions these approaches have reduced disease prevalence,their efficacy is rapidly diminishing.It is necessary to develop new control strategies for interrupting parasite transmission by the mosquito vector.Anopheles dirus,the main Southeast Asia malaria vector,is known to be susceptible to human malaria parasites,but naturally refractory to the rodent malaria parasite Plasmodium yoelii (Somboon et al.,1999).However,the mechanism by which A.dirus is naturally refractory to P.yoelii is undefined at present.
Jian Zhang Yanyan Wang Ying Wang Wenyue Xu Fu Sheng Huang
Department of The Pathogenic Biology, The Third Military Medical University, Chongqing 400038,PR China
国内会议
重庆
英文
61-62
2012-10-20（万方平台首次上网日期，不代表论文的发表时间）