Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3:A 26-week Intramuscular repeated administration study in rats

摘要：

　　The purpose of this study is to investigate the potential subchronic toxicity of a dammarane-type triterpenoid saponin with antitumor effect, 20(S)-Ginsenoside Rg3, by a 26-week repeated intramuscular administration in Wistar rats.20(S)-Ginsenoside Rg3 was administrated intramuscularly to both male and female rats (n =15 for male and female rats for each dose) at dose levels of 0, 4.2, 10.0 or 20.0 mg/kg/day.On week 13 of the treatment period, 4 rats/sex/group were sacrificed.On week 26 of the treatment period, 6 rats/sex/group were sacrificed.While 5 rats/sex/group were sacrificed after an 8-week recovery.

关键词： 20(S)-ginsenoside Rg3 Intramuscular administration Rats Subchronic toxicity

作者: Jinping Liua Dan Lua Qinghe Zhanga Haiyu Liua Miao Yua Wenjie Zhao ingya Li

作者单位: Institute of Frontier Medical Science of Jilin University,ChangChun,Jilin 130021,China

会议类型: 国内会议

会议名称: 2012中国吉林·国际人参大会(2012 International Conference on Ginseng·Jinlin China)

会议地点: 长春

会议语种:英文

页码: 292-293

在线出版日期: 2012-09-04（万方平台首次上网日期，不代表论文的发表时间）