An efficient and practical synthesis of ropivacaine hydrochloride under ultrasound irradiation

摘要：

　　Ropivacaine hydrochloride was synthesized from L-2-pipecolic acid by successive reaction with SOCl2 and 2,6-dimethylaniline at 40℃ under ultrasonic irradiation to yield L-N-(2,6-dimethylphenyl)-piperidin-2-carboxamide (4), and 4 was reacted with l-bromopropane at 50℃ for 1 h under ultrasonic irradiation.The effects of reaction solvent, temperature and time under ultrasonic irradiation were investigated.Compared with conventional methods, present procedures have the advantages in milder conditions, shorter reaction time and higher yields.The total yield was 67.5%, ”α”2o5=-6.6°(c =2, H2O).

关键词： ropivacaine local anaesthetic sonochemistry L-2-pipecolic acid

作者: Yi Liu Sai Li Xiaobin FU Li Liu Wenqi Meng Jingzheng Zhang Cong Cheng Nuo Lan Wen Cui

作者单位: Departrnent of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou,221002,Jiangsu, China; Environment Protection Research Institute of Xuzhou, Xuzhou, Jiangsu Province, China Department of Anesthesia, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, 221002, Jiangsu, Chi

会议类型: 国内会议

会议名称: 江苏省药理学会青年工作委员会成立大会暨药理学科青年科技创新学术研讨会

会议地点: 苏州

会议语种:英文

页码: 53-59

在线出版日期: 2013-05-24（万方平台首次上网日期，不代表论文的发表时间）