Protective role of Luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats
Chronic cerebral hypoperfusion, a mild ischemic condition, is associated with the cognitive deficits of Alzheimer”s disease (AD).Luteolin, a polyphenolic compound found in foods of plant origin, belonging to the flavone subclass of flavonoids, has been shown to possess antioxidant, anti-inflammatory and antitumorigenic properties.In the present study, the effects of luteolin on chronic cerebral hypoperfusion-assoeiated neurocognitive pathologies were investigated by using rats with permanent bilateral common carotid artery occlusion, a rat model of chronic cerebral hypoperfusion.As expected, we found that luteolin could attenuate cognitive dysfunction in ehronie cerebral hypoperfused rats, as assessed using Morris water maze tests.Daily oral administration of luteolin (50, 100 and 200 mg/kg) significantly scavenged oxygen free radicals, enhanced antioxidant potential, decreased the lipid peroxide production and suppressed inflammatory reaction in cerebral cortex and hippocampus induced by chronic cerebral hypoperfusion.Meanwhile, the results indicated that cerebral hypoperfusion activated nuclear factor-κB (NF-κB), increased the expression of β-site amyloid precursor protein cleaving enzyme (BACE1), as well as elevated amyloid beta (Aβ) levels in cortex and hippocampus.However, long-term administration of luteolin significantly down-regulated the expression of NF-κB and BACE1, accompanied by diminishing the deposition of Aβ.Our results suggest a potential therapeutic use of luteolin for cerebral hypoperfusion associated cognitive dysfunction in AD.
Luteolin Chronic cerebral hypoperfusion Antioxidant Anti-inflammatory Amyloid beta
Lingyan Sun Jingzheng Zhang Shuaishuai Wang Yan Feng Lingshan Gou Ling Zhang Yi Liu
School of Pharmacy, Xuzhou Medical College, Xuzhou 221004 Jiangsu Province, P.R.China
国内会议
江苏省药理学会青年工作委员会成立大会暨药理学科青年科技创新学术研讨会
苏州
英文
68-80
2013-05-24（万方平台首次上网日期，不代表论文的发表时间）