Timed high-fat diet in the evening affects the hepatic circadian clock and PPAR α-mediated lipogenic gene expressions in mice

摘要：

　　Purpose: A long-term high-fat diet may result in a fatty liver.However, whether or not high-fat diets affect the hepatic circadian clock is controversial.The objective of this study is to investigate the effects of timed highfat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated receptor (PPAR) α-mediated lipogenic gene expressions.Methods: Mice were orally administered high-fat milk in the evening for 4 weeks, and then sacrificed at the following time-points: 6:00, 12:00, 18:00 and 24:00, and 6 animals in each group were randomly sacrificed at each time point.

作者: Xiao-yan Wang Jie Xue Juan Yang Mei-lin Xie

作者单位: Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China

会议类型: 国内会议

会议名称: 江苏省药理学会青年工作委员会成立大会暨药理学科青年科技创新学术研讨会

会议地点: 苏州

会议语种:英文

页码: 173-174

在线出版日期: 2013-05-24（万方平台首次上网日期，不代表论文的发表时间）