Inhibition of LXRα/SREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule
Nonalcoholic fatty liver (NAFL) is increasingly recognized as one of the most common cause of chronic liver disease worldwide.Traditional Chinese Medicine (TCM), as the alternative and complementary medicine, may provide some profound health benefit.”Jiang-Zhi” Granule (JZG) was composed based on TCM pathogenesis of NAFL-the retention of inner dampness, heat and blood stasis.This study investigated effects of JZG on liver X receptor-α (LXRα)/Sterol regulatory element binding protein-1c (SREBP-1c) pathway in high-fat diet (HFD)-induced hepatic steatosis, as well as in rice fatty acid (FFA)-and T0901317-treated HepG2 cells.The results showed that JZG had an anti-steatotic effect in HFD-fed rats.JZG decreased the activation of SREBP-1c through inhibiting LXRα-mediated SREBP-1c transcription, as well as through inhibiting the maturation of SREBP-1c independent of LXRα.These findings may provide molecular evidence for the use of JZG as a promising therapeutic option for NAFL, and support us to continue JZG treatment in NAFL.For JZG treatment to be widely accepted, a randomized, double-blind, multicenter,placebo-controlled, phase Ⅲ trial is ongoing.
Miao Wang Shanshan Sun Guang Ji
Institute of Digestive Disease,Longhua Hospital,Shanghai University of Traditional Chinese Medicine, Institute of Digestive Disease,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,
国内会议
深圳
英文
81-81
2013-05-01（万方平台首次上网日期，不代表论文的发表时间）