Right Ventricular Structure and Function in Health and Disease
The right ventricle plays an important role in health and disease.Composed from progenitors of different embryologic than the left ventricle,the right ventricle looks,contracts,and compensates for increased volume or pressure load differently compared to the left ventricle.There are age,sex,and race differences in right ventricular structure and function in normal adults.Right ventricular hypertrophy increases the risk of heart failure or cardiovascular death even in adults without clinical cardiovascular disease at baseline,independent of other factors.The right ventricle plays a similarly important role in diseases characterized by increased afterload.Right ventricular dysfunction increases the risk of death in congestive heart failure.Lower right ventricular ejection fraction at baseline is independently associated with higher mortality in idiopathic pulmonary arterial hypertension.Even in parenchymal lung diseases (such as idiopathic pulmonary fibrosis),changes in right ventricular morphology are associated with long term outcomes.There have not been clinical trials of therapies targeted for the right ventricle in patients with (or at risk for)right ventricular dysfunction,however it is possible that specific interventions in patients could translate to improved outcomes.
Steven Kawut
University of Pennsylvania medical center
国内会议
北京
英文
25-25
2013-04-19（万方平台首次上网日期，不代表论文的发表时间）