Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin Ⅱ-Induced Inflammation and Cardiac Fibrosis

摘要：

　　Objective Inflammatory responses play a pivotal role in the pathogenesis of hypertensive cardiac remodeling.Macrophage recruitment and polarization contribute to the development of cardiac fibrosis.Although serumglucocorticoid regulated kinase 1 (SGK1) is a key mediator of fibrosis,its role in regulating macrophage function leading to cardiac fibrosis has not been investigated.We aimed to determine the mechanism by which SGK1 regulates the cardiac inflammatory process,thus contributing to hypertensive cardiac fibrosis.

作者: Min Yang Huihua Li Jizhong Cheng Jie Du Jiao Zheng Yanjv Miao Ying Wang Wei Cui Jun Guo Shulan Qiu Yalei Han Lixin Jia

作者单位: Beijing An Zhen Hospital, Capital Medical University, Beijing, China, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Institute o

会议类型: 国内会议

会议名称: 第七届北京五洲心血管病研讨会

会议地点: 北京

会议语种:英文

页码: 35-37

在线出版日期: 2013-04-19（万方平台首次上网日期，不代表论文的发表时间）