Deficiency of cathepsin S attenuates angiotensin Ⅱ-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

摘要：

　　Aims Abdominal aortic aneurysm (AAA) is characterized by extensive aortic wall matrix degradation that contributes to the remodelling and eventual rupture of the arterial wall.Elastinolytic cathepsin S (Cat S) is highly expressed in human aneurysmal lesions,but whether it contributes to the pathogenesis of AAA remains unknown.Methods and results AAAs were induced in apolipoprotein E (ApoE) and Cat S compound mutant (Apoe-/-Ctss-/-) mice and in ApoEdeficient Cat S wildtype littermates (Apoe-/-Ctss+/+) by chronic angiotensin Ⅱ infusion,and AAA lesions were analysed after 28 days.

作者: Yahweh Qin Guo-Ping Shi Xu Cao Jun Guo Yaozhong Zhang Lili Pan Hongjia Zhang Huihua Lil Chaoshu Tang Jie Du

作者单位: Beijing An Zhen Hospital, Capital Medical University The Key Laboratory of Remodeling-related Cardiovasctdar Diseases, Ministry of Education, Institute o Department of Medicine, Brigham and Women”s Hospital, Harvard Medical School, Pasteur, Boston, USA

会议类型: 国内会议

会议名称: 第七届北京五洲心血管病研讨会

会议地点: 北京

会议语种:英文

页码: 86-87

在线出版日期: 2013-04-19（万方平台首次上网日期，不代表论文的发表时间）