Relationship Between Plasma Level of inflammatory Marker and Platelet Aggregation in Patients With Clopidogrel Resistence after Angioplasty

摘要：

　　Objective The study evaluated the relationship between plasma markers of inflammation concentration and clopidogrel resistance in patients after stent implantation.METHODS.The plasma levels of CRP,P—selection,sCD40L,IL6 and platelet aggregation was measured by light transmittance aggregometry (LTA) in 352 patients undergoing PCI at baseline and 6month followup.Results The plasma levels of CRP,Pselection,sCD40L,IL6 was increased and higher in 65 patients (18.5%) with clopidogrel resistence group than normal responsiveness group at 6month after PCI.There was a significant positive correlation between Soluble CD40L levels and platelet aggregation (r =0.28,P < 0.05).Diabetes,a sCD40L level were independent predictors for unresponsiveness to patients after stent implantion according to stepwise multivariate analyses.The hazard ratio (HR) for clopidogrel resistance was 3.02 (95% CI=1.28 to 3.25;P=0.036).

作者: Hailong Ge Yujie Zhou Xiaoli Liu MD Yonghe Guo Wangjun Chen Qing Yang MD

作者单位: Anzhen Hospital, Capital Medical University

会议类型: 国内会议

会议名称: 第七届北京五洲心血管病研讨会

会议地点: 北京

会议语种:英文

页码: 102-102

在线出版日期: 2013-04-19（万方平台首次上网日期，不代表论文的发表时间）