G-protein beta3 subunit polymorphisms and essential hypertension:A case-control association study in Northern Han Chinese
Background and Objective Essential hypertension (EH) is a complex polygenetic disease influenced by the interaction of multiple susceptibility genes and environmental factors.Gproteins play a major role in signal transduction from the extracellular space into the cell and are associated with disease mechanisms.G protein beta3 subunit (GNB3) gene has been widely investigated as a candidate gene for EH.However,the results of association between the GNB3 gene variants (C825T,C1429T and G (-350) A) and EH are still controversial.We performed a case—control study including 731 hypertensive patients and 673 control subjects to explore the potential contribution of the GNB3 gene variants to the development of EH in the Northern Han Chinese.
G protein beta3 subunit gene polymorphism hypertension haplotype
Mei Li Shaojun Wen
Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases
国内会议
北京
英文
126-126
2013-04-19（万方平台首次上网日期，不代表论文的发表时间）