Rapamycin Regulates the Expression of Krüppel-Like Transcription Factor 2 Through nonphosphorylates and Activates Foxos
Backgrounds Previous studies identified KLF2 as a key ”molecular switch” that regulated the expression of TF,and eNOS.And we built on these initial observations and provided evidence that rapamycin induced the expression of KLF2 in human umbilical vein endothelial cells (HUVECs).PI (3,4,5) P3 mediates activation of protein kinase B,which phosphorylates and inactivates Foxos,thereby terminating expression of KLF2 and its target genes.We hypothesized that rapamycin might induce the expression and activity of KLF2 through nonphosphorylates and activates Foxos.
thrombosis rapamycin foxos endothelial cell kruppel-like transcription factor 2
Qian Ma Miao Yu Shiwei Yang Dean Jia Yujie Zhou
Capital Medical University Affiliated Beijing Anzhen Hospital and Institute of Heart
国内会议
北京
英文
165-165
2013-04-19（万方平台首次上网日期，不代表论文的发表时间）