Cross talk of NF-kappa B canonical and non-canonical pathway in human and mouse tissues
Background:Nuclear factor-kappa B (NF-κB) family are critical regulators in immunity,stress responses,apoptosis and differentiation,however,tissue NF-κB metabolism and their relevance to methylation status remain unknown.Method:We examined gene expression profiles of 5 NF-κB transcription factors,6 inhibitory IκB proteins (I-κB),3 Iκ B kinase (IKK) complex and 24 pathway components in NF-κB signaling pathway.Data-base mining of NF-κB family members and conponnets mRNA expressions are accomplished by querying GEO DataSets profiles under inflammation cytokine stimuli,hypomethylation status,and homocysteine treat.We analyzed correlations between gene expression,S-adenosylhomocysteine (SAH),and S-adenosylmethionine(SAM) levels,and SAM/SAH ratios in 7 mouse tissues.
Xiao Huang Ren Gong Xiao-feng Yang Hong Wang Xiao-shu Cheng
Department of Cardiology,Second hospital of Nanchang University,Nan Chang,Jiang Xi,China 330006;Depa Department of Pharmacology and Cardiovascular Research Center,Temple University School of Medicine,P Department of Cardiology,Second hospital of Nanchang University,Nan Chang,Jiang Xi,China 330006
国内会议
南昌
英文
237-237
2013-03-01（万方平台首次上网日期，不代表论文的发表时间）