Protein Microarray Analysis in a Mouse Cecal Ligation and Puncture Model for Early Prediction of Sepsis-Induced Disseminated Intravascular Coagulation

摘要：

　　Objective To identify valuable biomarkers of sepsis-induced disseminated intravascular coagulation (DIC) from platelets-derived factors by using a biotin label-based custom protein microarray technology in a mouse cecal ligation and puncture (CLP) model.Methods KM mice were randomized into sham-operated group and CLP group.Blood were detected immediately,at 1hr,2 hrs,6 hrs,12 hrs,24 hrs,48 hrs and 72 hrs after CLP for platelet count,coagulation assay and blood chemistries.

关键词： Protein Microarray,disseminated intravascular coagulation mice cecal ligation and puncture,platelets-derived factors

作者: Jingchun Song Zhaofen Lin Zili Chen Dunzhong Hu Chao He Tao Wang Xuefeng Liu Xi Wang Lv Wang Linhao Ma Jinlong Qu

作者单位: Department of emergency and critical care medicine,the 94th Hospital of PLA,Nanchang,Jiangxi Provinc Department of emergency and critical care medicine,Shanghai Changzheng Hospital,The Second Military

会议类型: 国内会议

会议名称: 江西省第六次中西医结合心血管学术交流会

会议地点: 南昌

会议语种:英文

页码: 298-299

在线出版日期: 2013-03-01（万方平台首次上网日期，不代表论文的发表时间）