Meta-analysis of studies on serotonin 2A receptor gene and susceptibility to major depressive disorder Running ritle:5-HTR 2A and susceptibility to MDD
Serotonin 2A receptor (5-HTR 2A) gene was implicated to be associated with major depressive disorder (MDD) susceptibility due to its role of key neurotransmitter in many physiologic processes.A great number of related studies reported in different populations have emerged.The results of these studies,however,have been inconsistent and thereby definite conclusions are difficult to establish.With the cumulative data in recent years,it was necessary to carry out a comprehensive analysis of previous findings.Therefore,we conducted the meta-analysis which combined all related studies using multiple research methods published up to January 2012 to give a new picture of the role of the 5-HTR 2A gene.In the meta-analysis of 19 case-control studies,including 2896 patients and 3709 controls,no significant association of MDD susceptibility with either T102C polymorphism or A-1438G polymorphism was found.When stratified by race for T102C polymorphism of the 5-HTR 2A,we also found no significant association.Compared with significant results reported previously,the current study did not support the association of the 5-HTR 2A gene with susceptibility to MDD.
Polymorphism Meta-analysis major depressive disorder Serotonin 2A receptor (5 -hydroxytryptamine 2A receptor) gene
Xue Zhao Liang Sun Ye-Huan Sun Cizao Ren Jian Chen Zhen-Qiang Wu Yu-Hong Jiang Xiao-Ling Lv
国内会议
江西省科协第二届学术年会暨华东地区第十一次流行病学学术交流会议
江西鹰潭
英文
482-482
2012-09-01（万方平台首次上网日期，不代表论文的发表时间）