Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis:a meta-analysis

摘要：

　　”Objective” The aim of the study was to determine whether the toll-like receptor 4 (TLR4) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and ankylosing spondylitis (AS).”Methods” A meta-analysis was conducted on the associaiton between the G299P/T399I polymorphisms and RA/AS (when available) using (1) the allelic contrast,(2) the recessive,(3) the dominant,and (4) the additive models.”Results” A total of 11 relevant studies met the inclusion criteria were identified,including RA:G299P (6 studies),T399I (3 studies) ; AS:G299P (5 studies),T399I (4 studies).Meta-analysis was performed with fixed/random effect models.Overall,no significant RA/AS risk was found in all genetic models when all studies were pooled into the meta-analysis (P > 0.05).”Conclusion” The present study might suggest that TLR4 G299P/T399I polymorphisms are not associated with RA/AS susceptibility.

关键词： Rheumatoid arthritis Ankylosing spondylitis Toll-like receptor 4 Polymorphism Meta-analysis

作者: Wang-Dong Xu Shah-Shan Liu Yu-Jing Zhang Rui Li Hai-Feng Pan Dong-Qing Ye

作者单位: Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Meishan Road,Hefei,Anhui,230032,PR China

会议类型: 国内会议

会议名称: 江西省科协第二届学术年会暨华东地区第十一次流行病学学术交流会议

会议地点: 江西鹰潭

会议语种:英文

页码: 484-485

在线出版日期: 2012-09-01（万方平台首次上网日期，不代表论文的发表时间）