HIV and HCV prevalence among entrants to methadone maintenance treatment clinics in China:a systematic review and meta-analysis

摘要：

　　”Background” Methadone maintenance treatment (MMT) was implemented in China since 2004.It was initiated in 8 pilot clinics and subsequently expanded to 738 clinics by the end of 2011.Numerous individual research studies have been conducted to estimate HIV and HCV prevalence among MMT clients but an overview of the epidemics in relations to MMT remains unclear.The aim of this study is to estimate the magnitude and changing trends of HIV,HCV and HIV-HCV co-infections among entry clients to MMT clinics in China during 2004-2010.”Methods” Chinese and English databases of literature were searched for studies reporting HIV,HCV and co-infection prevalence among MMT clients in China from 2004 to 2010.The prevalence estimates were summarized through a systematic review and meta-analysis of published literatures.”Results”Ninety eligible articles were selected in this review (2 in English and 88 in Chinese).Nationally,pooled prevalence of HIV,HCV and HIV-HCV co-infection among MMT clients was 6.0% (95% CI:4.7%-7.7%),60.1% (95% CI:52.8%-67.0%) and 4.6% (95% CI:2.9%-7.2%),respectively.No significant temporal trend was found in pooled prevalence estimates.Study location is the major contributor of heterogeneities of both HIV and HCV prevalence among drug users in MMT.”Conclusions” There was no significant temporal trend in HIV and HCV prevalence among clients in MMT during 2004-2010.Prevalence of HCV is markedly higher than prevalence of HIV among MMT clients.It is recommended that health educational programs in China promote the earlier initiation and wider coverage of MMT among injecting drug users (IDUs),especially HIV-infected IDUs.

关键词： HIV HCV Co-infection Prevalence Methadone maintenance treatment Meta-analysis China

作者: Xun Zhuang Yanxian Liang Eric P.F.Chow Yafei Wang David P.Wilson Lei Zhang

作者单位: School of Public Health,Nantong University,Jiangsu Province,China;The Kirby Institute,University of School of Public Health,Nantong University,Jiangsu Province,China The Kirby Institute,University of New South Wales,Sydney,Australia

会议类型: 国内会议

会议名称: 江西省科协第二届学术年会暨华东地区第十一次流行病学学术交流会议

会议地点: 江西鹰潭

会议语种:英文

页码: 486-486

在线出版日期: 2012-09-01（万方平台首次上网日期，不代表论文的发表时间）