Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway

摘要：

　　Matrix metalloproteinase-2 (MMP-2) is constitutively expressed in vascular smoothmuscle cells (VSMCs) and up-regulated in atherosclerotic lesion by various stimuli,such as oxidized low-density lipoprotein (oxLDL).Calcium-sensing receptor (CaSR) is also expressed in VSMCs,but it remains unclear whether CaSR is associated with overproduction of MMP-2 in VSMCs.In this study,the expression of MMP-2 was detected by real-time PCR and Western blot analysis,and the gelatinolytie activity of MMP-2 was measured using gelatin zymography.

作者: Hong-Xia Li Peng Xue Hong-Jiang Shao Hong-Zhu Li Shu-Zhi Bai Ye Tian Chang-Qing Xu

作者单位: Department of Pathophysiology, Harbin Medical University, Harbin 150086, China

会议类型: 国内会议

会议名称: 第二届全国抗衰老医学大会暨首届中国干细胞与抗衰老美容高峰论坛

会议地点: 沈阳

会议语种:英文

页码: 175-175

在线出版日期: 2012-08-01（万方平台首次上网日期，不代表论文的发表时间）