p12-LOX promotes skin carcinogenesis via up-regulating of Ezrin expression

摘要：

　　Accumulating evidence suggests that platelet-type 12-1ipoxygenase (pl2-LOX) and Ezrin play an important role in tumor development.However,how p12-LOX and Ezrin contribute to the skin carcinogenesis is still not well understood yet.This study is aimed to investigate the roles and mechanism of pl2-LOX and Ezrin in skin carcinogenesis,and to provide the effective target of chemoprevention for skin carcinogenesis.The mRNA expression of p12-LOX and Ezrin were significantly higher in B16 cell,followed by initiated JB6 P+ cell,then the normal JB6 P-cell,and its expression was further increased in JB6 P+ cells by tumor necrosis factor (TNF)-□.

关键词： p12-LOX Ezrin soft agar colony formation cloning efficiency target

作者: Jingchun Jin Huixin Lv Yunjie Hui Yue Ma Zhenhua Lin Yingshi Piao

作者单位: Cancer Research Center, Yanbian University Medical College, Yanji 133002 , China;Department of Hemat Cancer Research Center, Yanbian University Medical College, Yanji 133002 , China Cancer Research Center, Yanbian University Medical College, Yanji 133002 , China;Department of Patho

会议类型: 国内会议

会议名称: 第二届全国抗衰老医学大会暨首届中国干细胞与抗衰老美容高峰论坛

会议地点: 沈阳

会议语种:英文

页码: 177-177

在线出版日期: 2012-08-01（万方平台首次上网日期，不代表论文的发表时间）