TGFBR3, a Potential Negative Regulator of TGF-β Signaling, Protects Cardiac Fibroblasts from Hypoxia-Induced Apoptosis

摘要：

　　A lot of evidence indicates that cardiac fibroblasts are essential for maintaining the structure and function of heart.The present study examined whether TGFBR3 (transforming growth factor type Ⅲ receptor,also known as betaglycan) could prevent hypoxia-indueed injury in neonatal mice cardiac fibroblasts,if so,its possible molecular targets.MTT,electron microscopy and TUNEL assay were used to identify cell viability and apoptosis in neonatal mice cardiac fibroblasts.Results showed that hypoxia for 24 h markedly reduce cell viability by 49.8_8.9%,largely via apoptosis.

作者: Wenfeng Chu Hongli Shan Yanjie Lu Baofeng Yang Xiaoxue Li Cui Li Lin Wan Hui Sshi Xiaohui Song Xingyuan Liu Xi Chen Chun Zhang

作者单位: Department of Pharmacology, The State-Province Key Laboratories of Biomedieine-Pharmacentics of China, Harbin Medical University, Harbin, PR China

会议类型: 国内会议

会议名称: 第二届全国抗衰老医学大会暨首届中国干细胞与抗衰老美容高峰论坛

会议地点: 沈阳

会议语种:英文

页码: 178-178

在线出版日期: 2012-08-01（万方平台首次上网日期，不代表论文的发表时间）