Wogonin induced calreticulin/Annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner
In response to ionizing irradiation and certain chemotherapeutic gents,dying tumor cells elicit a potent anticancer immune response.However,the potential effect of wogonin (5,7-dihydroxy-8-methoxyflavone) on cancer immunogenicity has not been studied.Here we demonstrated for the first time that wogonin elicits a potent antitumor immunity effect by inducing the translocation of calreticulin (CRT) and Annexin A1 to cell plasma membrane as well as the release of high-mobility group protein 1 (HMGB1) and ATP.
tumor cell vaccine calreticulin HMGB1 p22 Annexin A1 ER stress DNA-PKcs phosphoinositide 3-kirase pathway
Yong Yang
China Pharmaceutical University
国内会议
南京
英文
2-2
2012-07-01（万方平台首次上网日期，不代表论文的发表时间）