Metabonomic Approach to Understanding Adriamycin Resistance in Breast Cancer Cells

摘要：

　　Since chemoresistance is a complicated and multifactorial factor in breast cancer,systematically characterize metabolic perturbation of endogenous compounds associated with drug resistance may providecandidate biomarkers or novel drug targets.The current study examined the different metabolites between senstivebreast cancer MCF-7/S and adriamycin-resistant MCF-7/Adr and their differentresponse to adriamycin.GC-TOF/MS-based metabonomic analysis revealed the different metabolic patterns between these two cell lines and the discriminatory metabolites suggested the nucleotides metabolism,glutathione biosynthesis,glucose metabolism and glycerol metabolism were reprogrammed.These

关键词： metabolomics drug resistance breast cancer nucleotides metabolism glutathione biosynthesis glucose metabolism glycerol metabolism biomarkers

作者: Bei Cao Jiye A Guangji Wang Weibin Zha Qijin Zhao Beth S.Zha Rongrong Gu Linsheng Liu Jian Shi Xiaolan Wu Fang Zhou

作者单位: Lab of Metabolomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical Un Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, Virginia, 23298

会议类型: 国内会议

会议名称: 江苏省药理学会第六届学术研讨会

会议地点: 南京

会议语种:英文

页码: 162-163

在线出版日期: 2012-07-01（万方平台首次上网日期，不代表论文的发表时间）