The Role of Holothurian glycosaminoglycan as a Metastasis Suppressor in P-selectin induced Melanoma Cancer Cells B16F10 mobility and angiogenesis
The dynamic crosstalk between cancer and platelet is increasingly recognized as a key regulator of malignant progression.Tumor cells are known to secrete several cytokines,which activate platelet and induce tumor thrombus formation.In turn,activated platelets provide instructive signals that affect tumor cell behavior and metastatic potential.One of the main markers for platelet activation is P-selectin,and platelet-tumor cell interactions and the signaling pathways that P-selectin trigger are therefore crucial determinants of cancer metastasis and potential target for anti-metastatic therapies.
Holothurian glycosaminoglycan melanoma cells molecule docking migration P-selectin
Zhiqiang Yue Yin Lu
Department of Clinical Pharmacy;College of Pharmacy Department of Clinical Pharmacy;College of Pharmacy;Jiangsu Key Laboratory of Efficacy and Safety Ev
国内会议
南京
英文
163-163
2012-07-01（万方平台首次上网日期，不代表论文的发表时间）