The Aggregation Behavior and Formation of Nanoparticles of Oleoylchitosan in Dilute Aqueous Solution
Oleoylchitosans(O-chitosans),with different degrees of substitution(DS),were synthesized by reacting chitosan with oleoyl chloride.The chemical structures of products were characterized by 1H NMR,FT-IR.These results suggested the formation of an amide linkage between amino groups of chitosan and carboxyl groups of oleic acid.The viscosity of O-chitosan sharply increased with the increase of concentration,whereas that of unmodified chitosan rose only slightly.This increase was stronger as the increase of DS.All of the O-chitosans could reduce surface tension slightly.The critical aggregation concentration(CAC)of O-chitosans with DS 5,11,and 27% were 79.43,31.6,and 10 mg/L,respectively.Nanoparticles were prepared using an O/W emulsification method.Mean diameters of the polymeric amphiphilic nanoparticles of O-chitosans with DS 5 and 11% were around 327.4 nm and 275.3 nm.
O-chitosan viscosity surface tension fluorescence nanoparticles
Li Yan-yan Chen Xi-guang
College of Marine Life Science,Ocean University of China,Qingdoo 266003,China
国内会议
青岛
英文
86-98
2007-08-01（万方平台首次上网日期，不代表论文的发表时间）