Hot Property of Aconiti Lateralis Radix Praeparata Processed Products and its Compatibility with Zingiberis Rhizoma Based on Animal Temperature Tropism
Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aeoniti Lateralis Radix Praeparata (ALRP) processed products and its compatibility with Zingiberis Rhizoma (ZR) on animal temperature tropism.Methods The equipment with cold/hot pads was used to investigate the variety of temperature tropism among mice treated by ALRP and its compatibility with ZR.Meanwhile,the activities of adenosine triphosphatase (ATPase),total anti-oxidant capability (T-AOC),and total superoxide dismutase (T-SOD) were measured.Results Compared with the homologous ALRP group,the compatibility between ALRP and ZR (AZ) had a stronger action against the decreasing of remaining rate on hot pad (P < 0.05),suggesting an enhancement of cold tropism.Meanwhile,the internal indexes of Na+-K +-ATPase activity,Ca2+-Mg2+-ATPase activity,and oxygen consuming volume increased significantly (P < 0.05),suggesting an enhancement of energy metabolism.The changes of T-AOC and T-SOD activity suggested that AZ reinforced the anti-oxidative capability of mice.In addition,it could be inferred from cluster analysis that the activity of AZ was concretely stronger than that of homologous ALRP.Conclusion ALRP and ZR are both herbs with hot property,but AZ has an enhanced trend of hot property.This external behavior of cold tropism and the internal activity of energy metabolism and anti-oxidant might reflect the internal hot property in an intuitive and objective way.The changes of ATPase activity of liver tissue might be the mechanism of drug action.
Aconiti Lateralis Radix Praeparata animal temperature tropism clustering analysis compatibility Zingiberis Rhizoma
SUN Zhi-yong ZHAO Yan-ling WANG Jia-bo LI Rui-sheng WEI Si-si JIANG Feng-juan XIAO Xiao-he
Integrative Medicine Center of 302 Military Hospital, China Military Institute of Chinese Materia Me Integrative Medicine Center of 302 Military Hospital, China Military Institute of Chinese Materia Me Animal Laboratory Center, 302 Hospital of PLA, Beijing 100039, China
国内会议
杭州
英文
80-86
2012-11-30（万方平台首次上网日期，不代表论文的发表时间）