The Mycobacterium tuberculosis Beijing strains favor transmission but not drug resistance in China
Background The Mycobacterium tuberculosis Beijing strains are widespread globally.We aimed to determine whether Beijing strains in China are more likely than other strains to spread,and whether they are more likely to become drug stant.We also sought to determine whether different Beijing sublineages have distinct phenotypic characteristics.We conducted a population-based molecular epidemiologic study in six provinces in China from 2009 to 2010.We analyzed data and specimens from culture-confirmed pulmonary tuberculosis patients.Each patient”s isolate was genotyped using 16-loci variable number of tandem repeats (VNTR) and 6 single nucleotide polymorphisms (SPNs).ResultsBy genotyping,75.0% (1031/1375) of the strains of M.tuberculosis were Beijing strains.Beijing strains were more likely than non-Beijing strains to be in a genotypic cluster (odds ratio,2.40,P <.001),and were significantly associated with younger age (P trend <.05).There was no significant difference in the proportion of Beijing strains and non-Beijing strains that were drug-resistant,even when stratified by new versus retreatment patients.We identified six sublineages of Beijing strains in the study population.The modem sublineage of Beijing strains were more likely than the ancient sublineages to be clustered (odds ratio,2.27,P <.001).
Chongguang Yang Tao Luo Guomei Sun Ke Qiao Gang Sun Kathryn DeRiemer Jian Mei Qian Gao
Key Laboratory of Medical Molecular Virology,Institutes of Biomedical Sciences and Institute of Medi University of California,Davis,School of Medicine,One Shields Avenue,Davis,California 95616 Department of TB Control,Shanghai Municipal Center for Disease Control and prevention,1380 West Zhon
国内会议
武夷山
英文
59-87
2012-12-22（万方平台首次上网日期，不代表论文的发表时间）