Repair of heat-induced skin aging by herbal extracts and thermal protection factor (TPF)
Long term exposure of skin to high temperature induces activation of transient receptor potential cation channel subfamily V member 1 (TRPV-1),as well as increase of matrix metalloprotease 9 (MMP-9),which breaks down extracellular matrix in skin.Thus,along with photo-aging,heat also accelerates skin-aging as a long term effect.Here,heat-absorbing substances with heat energy-blocking effects were screened,and the blockage rate was calculated as ”Thermal Protection Factor (TPF)”.Herbal plant extracts such as Prunus Mume fruit extract and Chamaecyparis Obtusa polysaccharide were able to reduce skin damage by reducing TRPV-1 activation,heat-induced MMP-9 expression and other heat-induced inflammatory responses such as monocyte chemoattractant protein-1 (MCP-1) expression.Also,a cream containing heat-absorbing and modulating actives showed statistically significant skin elasticity and redness-controlling effects in a clinical study.
Heat, skin aging TPF Prunus Mume Chamaecyparis Obtusa TRPV-1
Hyeon Chung Kim Jeong Cheol Ha Su Sun An Jae Ho Yeon Kuan Chi Hsu Sung Il Park Eui Dong Son Myeong Hoon Yeom Dae Jin Min Sang Hoon Han Hak Hee Kang Quen Quen He
Amorepacific Corporation R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si,Gyeonggi-do, 446-729 Re Amorepacific Shanghai R&I Center China, Shanghai, China
国内会议
上海
英文
570-574
2012-09-01（万方平台首次上网日期，不代表论文的发表时间）