Evaluation of the immune response induced by DNA vaccines expressing MIF and MCD-1 genes of Trichinella spiralis in BALB/c mice

摘要：

　　Plasmids expressing macrophage migration inhibitory factor (MIF) of Trichinella spiralis (TsMIF),multi-cystatin-like domain protein (MCD-1) of T.spiralis (TsMCD-1),or co-expressing TsMIF and TsMCD-1 were constructed with a pVAX1 vector.Their ability to generate a protective immune response against T.spiralis infection was evaluated in BALB/c mice.Groups of mice were immunized twice at 2-week intervals with 100 mg of recombinant plasmids pVAX1-Tsmif,pVAX1-Tsmcd-1 or pVAX 1-Tsmif-Tsmcd-1.

关键词： T.spiralis MIF MCD-1 DNA vaccine BALB/c mice

作者: Fang Tang Lixin Xu Ruofeng Yan Xiaokai Song Xiangrui Li

作者单位: College of Veterinary Medicine,Nanjing Agricultural University,Nanjing,210095,China

会议类型: 国内会议

会议名称: 中国畜牧兽医学会兽医食品卫生学分会第十二届学术研讨会

会议地点: 长春

会议语种:英文

页码: 346-346

在线出版日期: 2012-12-01（万方平台首次上网日期，不代表论文的发表时间）