Hsp90 N-terminal inhibitor 17-AAG and C-terminal inhibitor cisplatin synergistically eradicates Bcr-Abl-positive human leukemia progenitor/stem cells

摘要：

　　Hsp90 is a ubiquitous molecular chaperone that regulates over 200 client proteins involved in multiple growth and signaling pathways,which are targets for chemotherapeutic strategies.Thus,Hsp90”s role as a master regulator has made it an attractive candidate for drug development.Hsp90 exists.as a homodimer in the cytosol,with three highly conserved domains.Both amino(N-) and carboxyl(C-) terminal domains of Hsp90 interact to cochaperones or ATP and then modulate chaperone activity.

作者: Lixian Wu Jianhua Xu Lisen Huang Ruijia Chen Meijuan Huang Yuanzhong Chen

作者单位: Dept.of Pharmacology;Institute of Materia Medica;Fuijan Key Laboratory of Natural Medicine Pharmacol Fujian Institute of Hematology,Union Hospital,FMU,Fuzhou,China

会议类型: 国内会议

会议名称: 2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会

会议地点: 深圳

会议语种:英文

页码: 405-407

在线出版日期: 2012-07-13（万方平台首次上网日期，不代表论文的发表时间）